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Alterations in the apoptosis of immune cells have been associated with autoimmunity. Here, we have identified a homozygous missense mutation in the gene encoding the base excision repair enzyme Nei endonuclease VIII-like 3 NEIL3 that abolished enzymatic activity in 3 siblings from a consanguineous family. The NEIL3 mutation was associated with fatal recurrent infections, severe autoimmunity, hypogammaglobulinemia, and impaired B cell function in these individuals. The same homozygous NEIL3 mutation was also identified in an asymptomatic individual who exhibited elevated levels of serum autoantibodies and defective peripheral B cell tolerance, but normal B cell function.
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His research interests include analysis of music in the electronic media, post-tonal theory in the 20th century, Schenkerian analysis, musical signification, music theory pedagogy, and wind band music history. He has published articles for the Journal of Music Theory, College Music Symposium, and Indiana Theory Review, has contributed chapters to several books on music and film, and is currently writing the article on television music in the New Grove Dictionary of American Music. Caviani has taught at St.
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Join us for this educational event and earn 1. Some of the highest incidence rates of CLL occur in the rural states of Montana, Maine, North Dakota, South Dakota, and Kentucky, where disparities in cancer care are also known to exist. Target Audience This activity is designed for multidisciplinary healthcare providers including physicians, nurses, pharmacists, and other allied healthcare professionals in rural practices who provide medical care to patients with CLL. Learning Objectives Upon completion of this educational activity, participants should be able to:. Accordingly, the following disclosures were made.
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