Whether you or a loved one are worried about developing breast cancer, have just been diagnosed, are going through breast cancer treatment, or are trying to stay well after treatment, this detailed information can help you find the answers you need. For information on breast cancer in men, see Breast Cancer in Men. Get basic information about breast cancer, such as what it is and how it forms, as well as the signs and symptoms of the disease. Learn about the various risk factors, both genetic and lifestyle-related , as well as prevention methods for breast cancer from the American Cancer Society. Get detailed information about breast cancer detection through tests such as mammograms, ultrasounds, other imaging tests and biopsies. Get the information you need to understand your breast cancer diagnosis with details on the various types of breast cancer, grading, hormone status, staging, and prognosis.
Notch Signaling Activation as a Hallmark for Triple-Negative Breast Cancer Subtype
Playlist : Thinking Pink: Songs for Breast Cancer Awareness : Napster
What separates a malignant from a normal cell? This question has occupied scientists for decades. Although a simple answer remains elusive, several hallmarks of malignancy have been identified. These critical features include uncontrolled proliferation, insensitivity to negative growth regulation, evasion of apoptosis, lack of senescence, invasion and metastasis, angiogenesis and genomic elasticity. Existing therapies predominantly target proliferation either with cytotoxic agents, ionising radiation or more targeted attacks on growth factor signalling pathways.
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The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis. Underlying these hallmarks are genome instability, which generates the genetic diversity that expedites their acquisition, and inflammation, which fosters multiple hallmark functions. Conceptual progress in the last decade has added two emerging hallmarks of potential generality to this list—reprogramming of energy metabolism and evading immune destruction.
Researchers have unveiled what they believe is a hallmark study for breast cancer patients and the doctors who treat them, according to the Pa. Breast Cancer Coalition. The project, funded by a large federal grant, focused on a genetic analysis of breast cancer, which kills more than 12, women in Pennsylvania each year.