Metrics details. Medulloblastoma MB is the most common malignant brain tumour in children but also rarely occur in adults. SMO inhibitors, sonidegib and vismodegib, have been used as selective antagonist of the hedgehog pathway that acts by binding to SMO, and inhibits activation of the downstream hedgehog target genes. Several clinical trials investigating SMO inhibitors for the treatment of relapsed MB patients have been published. We conducted a systemic review and meta-analysis among these Phase I and II clinical trials.
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Nicky Hughes has white skulls painted on her black shoes. She loves skulls and alternative clothing and reptiles. On her lifestyle block, along with two beefies, chickens and pigs, she has turtles and lizards. The cold blooded critters appeal to her because they are different, she says. Like her.
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Neural stem cells exist in the developing and adult nervous systems of all mammals, but the basic mechanisms that control their behavior are not yet well understood. Here, we investigated the role of Sonic hedgehog Shh , a factor vital for neural development, in regulating adult hippocampal neural stem cells. We found high expression of the Shh receptor Patched in both the adult rat hippocampus and neural progenitor cells isolated from this region. In addition, Shh elicited a strong, dose-dependent proliferative response in progenitors in vitro.