Please do not call our clinics or hospitals with questions. Rectal problems are common. Almost everyone will experience some rectal itching, pain, or bleeding at some time during his or her life. These problems are often minor and may go away on their own or with home treatment. Rectal itching pruritus is usually not a sign of a serious disease.
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Rectal administration uses the rectum as a route of administration for medication and other fluids, which are absorbed by the rectum's blood vessels , [Note 1] and flow into the body's circulatory system , which distributes the drug to the body's organs and bodily systems. A drug that is administered rectally will in general depending on the drug have a faster onset, higher bioavailability , shorter peak, and shorter duration than oral administration. In addition, the rectal route bypasses around two thirds of the first-pass metabolism as the rectum's venous drainage is two thirds systemic middle and inferior rectal vein and one third hepatic portal system superior rectal vein. This means the drug will reach the circulatory system with significantly less alteration and in greater concentrations.
Anal fissures are cracks or tears in the skin around your anus. The crack in the skin exposes the muscle underneath, causing burning and sharp pain when you have a bowel movement. The pain can last for hours after the bowel movement and can be severe. These cracks are usually caused by the passage of a hard stool but also can be caused by persistent diarrhea.